Immunoblot test with rubella virus lysate for the detection of IgG antibodies against the Rubella virus. Differentiation test for exclusion of a Rubella primary infection.

German measles caused by the Rubella virus typically appear during childhood and take a mild course in most cases – in many cases even proceed asymptomatically. However severe damage can occur in unborn children if the mother becomes infected with the virus shortly before pregnancy or within the first few months of pregnancy. Infections during organ differentiation within the first 12 weeks of pregnancy should be considered particularly alarming. The outcome can be spontaneous abortion, premature birth or the “Rubella syndrome”, the complete clinical picture for which is known as impairment of the heart, eye and inner ear (classic triad), also called Gregg’s syndrome. The risk of embryopathy decreases during the further course of pregnancy. Infection past the 20th week of pregnancy is generally regarded to have no impact on the foetus.

An accurate serological determination of Rubella antibody status is exceptionally important for pregnant women, if an acute infection with Rubella virus is suspected or in case of an imperfect vaccination.

The recomBlot Rubella IgG uses Rubella virus lysate produced in Vero cells. All Rubella specific antigens which are important for a accurate serological determination are presented by electrophoretic separation and subsequent transfer to a nitrocellulose membrane (Western Blotting). IgG conformation antibodies against the Rubella antigen E2 appear three month after vaccination or infection at the earliest. An infection within the last three month can be serologically ruled out if the E2 band is detectable.

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