T-Track® TB:
T-Track® TB Stimulation /
T-Track® TB Quant PCR
RT-qPCR assay as an aid in the diagnosis of M. tuberculosis infection (including active disease), via highly sensitive determination of the relative expression of TB antigen-induced, specific markers.
According to the World Health Organization (WHO), tuberculosis (TB) is one of the top 10 causes of death worldwide. TB is caused by Mycobacterium tuberculosis. It typically affects the lung (pulmonary TB) but can also affect other organs (extrapulmonary TB). About 25% of the world’s population is latently infected with
M. tuberculosis and at risk of developing active TB disease if not treated. Patients under immunsuppression, e.g. therapeutically induced in case of transplantations or rheumatic disorders, are especially at risk.
T-Track® TB is a qualitative diagnostic test, suitable for screenings, to determine TB-specific reactivity of T-cells. Based on a patented technology, this RT-qPCR-based test is intended for use as an aid in the diagnosis of M. tuberculosis infection (including active disease).
The T-Track® TB assay consists of two diagnostic kits:
1. T-Track® TB Stimulation: Stimulation of TB-specific immune cells, via incubation with TB antigens, followed by stabilization of RNA.
2. T-Track® TB Quant PCR: Measurement of the relative expression of specific classification markers via reverse transcription and quantitative PCR (RT-qPCR). Software based analysis.
Differential expression levels of the classification markers in stimulated and unstimulated blood samples may indicate an infection with M. tuberculosis. Results must be interpreted within the context of all relevant clinical and laboratory findings.
T-Track® TB: T-cell assay for improved diagnostics
- CE-marked IVD (in vitro diagnostic product) – RT-qPCR
- Aid in the diagnosis of M. tuberculosis infection (including active disease
- Highly-sensitive, patented technology: Including marker also for the early phase of infection
- Measurement and analysis of the relative expression of the specific markers IFNG and CXCL10, after in vitro stimulation of immune cells with the TB antigens ESAT-6 und CFP-10
- Easy handling, standardized and semi-automated processing
- Software based analysis
